منابع مشابه
Microbial genomes: dealing with diversity.
We have now complete genome sequences of several pairs of closely related prokaryotes (conspecific strains or congeneric species). Surprisingly, even strains of the same species can differ by as much as 20% in gene content. Conceptual and methodological approaches for dealing with such diversity are now being developed, and should transform microbial genomics.
متن کاملEvolutionary Mechanisms of Microbial Genomes
1Agricultural Bioinformatics Research Unit, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan 2Laboratory for Cellular Systems Modeling, RIKEN Research Center for Allergy and Immunology, Kanagawa 230-0045, Japan 3Laboratory of Environmental Biochemistry, Biotechnology Research Center, The University of Tokyo, Tokyo 113-8657, Japan 4Gene Expression...
متن کاملThree views of microbial genomes.
We describe here GenomeAtlases as a method for visualising three different aspects of complete microbial chromosomes: repeats, DNA structural characteristics, and base composition. We have applied this method to all publicly available genomes, and find a general strand preference of global repeats. The atlas for the Mycoplasma genitalium genome is presented as an example, and results from all t...
متن کاملThe Enhanced Microbial Genomes Library
Since the obtention of the complete sequence of Haemophilus influenzae Rd in 1995, the number of bacterial genomes entirely sequenced has regularly increased. A problem is that the quality of the annotations of these very large sequences is usually lower than those of the shorter entries encountered in the repository collections. Moreover, classical sequence database management systems have dif...
متن کاملConcordance analysis of microbial genomes.
The set of proteins which are conserved across families of microbes contain important targets of new anti-microbial agents. We have developed a simple and efficient computational tool which determines concordances of putative gene products that show sets of proteins conserved across one set of user specified genomes and not present in another set of user specified genomes. The thresholds and th...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 1999
ISSN: 0950-382X,1365-2958
DOI: 10.1046/j.1365-2958.1999.01427.x